![]() Likewise, understanding the regulation of Th2 immunity in asthma and allergy will provide us with a catalog of molecules and pathways that could be targeted for disruption by parasite-derived molecules. It is anticipated that an understanding of the mechanism of action of the parasite-derived molecules on the immune response will inform us of the molecular and cellular bases for the generation and regulation of asthma and allergy in humans. ![]() In the second line of research we study filarial nematode infections with the goal of identifying the molecules released by the parasite that modify the immune responsiveness of the host and result in a highly polarized Th2 immunity and chronic infection. The first line of investigation concentrates on the use of a murine model of human asthma and allergy to define the genetic and molecular determinants that result in the disregulation of immune response to traditional allergens. In these studies the lab has taken on two lines of investigation that have a common theme of defining the molecular basis for control of Th2 responses. The specific focus of this interest is on the ability of certain helminth parasites to actively modify host immunity and control the Th1-Th2 axis of the immune response. ![]() My laboratory is interested in understanding the immunobiology of host-parasite interactions.
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